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particular embodiment, the presence of PD-L1 is determined using an automated IHC
assay. CD28 family. PD-1 is expressed predominantly on previously activated T cells in vivo,
and binds to two ligands, PD-L1 and PD-L2.
The use of the term "fixed dose" with regard to a composition of the invention means that two or more different antibodies in a single composition are present in the composition in particular (fixed) ratios with each other.
13. A composition comprising the antibody of claim 1 and a
pharmaceutically acceptable carrier. 7. The antibody of claim 2, wherein the antibody blocks the binding and/or the interaction of an ICOS
ligand to human ICOS. Deng Z-B, et al., "An agonist human ICOS monoclonal antibody that induces T cell activation and inhibits proliferation of a myeloma cell line," Hybridoma and Hybridomics, vol.
A "human" antibody (HuMAb) refers to an antibody having variable regions in which both the
framework and CDR regions are derived from human germline immunoglobulin sequences.
The constant regions of the antibodies may mediate the binding of the immunoglobulin to host
tissues or factors, including various cells of the immune system (e.g.,
effector cells) and the first component (Clq) of the classical
complement system.